B cell tolerance is achieved in part through secondary rearrangements that replace ('edit') exons encoding autoreactive antigen-receptor chains. New findings suggest that Foxo transcription factors are critical regulators of receptor editing by activating the transcription of recombination-activating genes.
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Kim Caesar
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Rowh, M., Bassing, C. Foxos around make B cells tolerable. Nat Immunol 9, 586–588 (2008). https://doi.org/10.1038/ni0608-586
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DOI: https://doi.org/10.1038/ni0608-586
