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Moving out: mobilizing activated T cells from lymphoid tissues

Nature Immunology volume 9, pages 455–457 (2008)Cite this article

The intensity of cytokine-induced signaling by the kinase PI(3)K subunit p110δ proves to be an important regulator of T cell migration patterns. High PI(3)K activity functions through the nutrient and bioenergetic sensor mTOR to modulate the transcription factor KLF2 and thereby the repertoire of tissue-homing receptors expressed on effector T cells.

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Figure 1: PI(3)K in T cell trafficking activity.

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Authors and Affiliations

  1. Gabriel Berstein is with Inflammation Discovery Research, Wyeth, Cambridge, Massachusetts 02140, USA.,

    Gabriel Berstein

  2. Robert T. Abraham is with Oncology Discovery Research, Wyeth, Pearl River, New York 10960, USA. abrahar@wyeth.com,

    Robert T Abraham

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  1. Gabriel Berstein
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  2. Robert T Abraham
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G.B. and R.T.A. are employees of Wyeth.

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Berstein, G., Abraham, R. Moving out: mobilizing activated T cells from lymphoid tissues. Nat Immunol 9, 455–457 (2008). https://doi.org/10.1038/ni0508-455

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