Smad7 controls inflammation by negatively regulating activation of the transcription factor NF-κB. New work shows that Smad7 inhibits NF-κB by binding to the regulatory proteins TAB2 and TAB3, thereby blocking association of the E3 ubiquitin ligase TRAF2 with the kinase TAK1.
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Seth, R., Chen, Z. Smads keep TABs on inflammation. Nat Immunol 8, 477–478 (2007). https://doi.org/10.1038/ni0507-477
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DOI: https://doi.org/10.1038/ni0507-477
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