Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Resolving a case of split personality

The function of prostaglandin E2 in allergy has long been ambiguous. Now a comprehensive assessment of prostaglandin E2 receptor–deficient mice demonstrates the main anti-inflammatory function of this prostaglandin in allergic lung disease.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Prostaglandin biosynthesis, receptors and chief associations with allergic inflammation.

References

  1. Kunikata, T. Nat. Immunol. 6, 524–531 (2005).

    Article  CAS  Google Scholar 

  2. Profita, M. et al. J. Allergy Clin. Immunol. 112, 709–716 (2003).

    Article  CAS  Google Scholar 

  3. Wu, C.Y., Wang, K., McDyer, J.F. & Seder, R.A. J. Immunol. 161, 2723–2730 (1998).

    CAS  PubMed  Google Scholar 

  4. Gomi, K., Zhu, F.G. & Marshall, J.S. J. Immunol. 165, 6545–6552 (2000).

    Article  CAS  Google Scholar 

  5. Kolenko, V. et al. Blood 93, 2308–2318 (1999).

    CAS  PubMed  Google Scholar 

  6. Roper, R.L., Brown, D.M. & Phipps, R.P. J. Immunol. 154, 162–170 (1995).

    CAS  PubMed  Google Scholar 

  7. Pene, J. et al. Proc. Natl. Acad. Sci. USA 85, 6880–6884 (1988).

    Article  CAS  Google Scholar 

  8. Rieser, C., Bock, G., Klocker, H., Bartsch, G. & Thurnher, M. J. Exp. Med. 186, 1603–1608 (1997).

    Article  CAS  Google Scholar 

  9. Kalinski, P., Hilkens, C.M., Snijders, A., Snijdewint, F.G. & Kapsenberg, M.L. J. Immunol. 159, 28–35 (1997).

    CAS  PubMed  Google Scholar 

  10. Hata, A.N. & Breyer, R.M. Pharm. Thera. 103, 147–166 (2004).

    Article  CAS  Google Scholar 

  11. Fedyk, E.R. & Phipps, R.P. Proc. Natl. Acad. Sci. USA 93, 10978–10983 (1996).

    Article  CAS  Google Scholar 

  12. Tilley, S.L. et al. Am. J. Physiol. Lung Cell Mol. Physiol. 284, L599–606 (2003).

    Article  Google Scholar 

  13. Martin, J.G. et al. J. Immunol. 169, 3963–3969 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Corry, D. Resolving a case of split personality. Nat Immunol 6, 432–434 (2005). https://doi.org/10.1038/ni0505-432

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0505-432

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing