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Do NK cells always need a license to kill?

The ability of natural killer cells to eliminate abnormal cells has been shown to be enhanced by triggering of certain inhibitory receptors during their maturation. New data show that sometimes the opposite can happen.

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Figure 1: Differences in the responsiveness of licensed and unlicensed NK cells.

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Correspondence to André Veillette.

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Cruz-Munoz, ME., Veillette, A. Do NK cells always need a license to kill?. Nat Immunol 11, 279–280 (2010). https://doi.org/10.1038/ni0410-279

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