Deubiquitinating enzymes remove polyubiquitin chains from and alter the fate of specific target proteins. The CYLD deubiquitinating enzyme regulates proximal T cell receptor signaling in thymocytes by selectively binding to and deubiquitinating the active form of the kinase Lck.
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Katie Ris
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Lineberry, N., Fathman, C. CYLD: deubiquitination-induced TCR signaling. Nat Immunol 7, 369–370 (2006). https://doi.org/10.1038/ni0406-369
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DOI: https://doi.org/10.1038/ni0406-369
