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MAPK p38: alternative and nonstressful in T cells

The MAP kinase p38 is normally regulated by the MAPKKK-MAPKK pathway in mammalian cells. However, analysis of T cell signaling shows an alternative pathway for p38 activation exists.

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Figure 1: Alternative p38 activation pathway in T cells.

Katie Ris

References

  1. Salvador, J.M. et al. Nat. Immunol. 6, 390–395 (2005).

    Article  CAS  Google Scholar 

  2. Salvador, J.M. et al. Nat. Immunol. 6, 396–402 (2005).

    Article  CAS  Google Scholar 

  3. Chang, L. & Karin, M. Nature 410, 37–40 (2001).

    Article  CAS  Google Scholar 

  4. Davis, R.J. Cell 103, 239–252 (2000).

    Article  CAS  Google Scholar 

  5. Bellon, S. et al. Structure Fold. S Des. 7, 1057–1065 (1999).

    Article  CAS  Google Scholar 

  6. Tanaka, N. et al. EMBO Rep. 3, 785–791 (2002).

    Article  CAS  Google Scholar 

  7. Dong, C. et al. Annu. Rev. Immunol. 20, 55–72 (2002).

    Article  CAS  Google Scholar 

  8. Samelson, L.E. Annu. Rev. Immunol. 20, 371–394 (2002).

    Article  CAS  Google Scholar 

  9. Ge, B. et al. Science 295, 1291–1294 (2002).

    Article  CAS  Google Scholar 

  10. Ohkusu-Tsukada, K. et al. Mol. Cell Biol. 24, 6957–6966 (2004).

    Article  CAS  Google Scholar 

  11. Salvador, J. et al. Immunity 16, 499–508 (2002).

    Article  CAS  Google Scholar 

  12. Gong, Q. et al. Nat. Immunol. 2, 29–36 (2001).

    Article  CAS  Google Scholar 

  13. Takekawa, M. & Saito, H. Cell 95, 521–530 (1998).

    Article  CAS  Google Scholar 

  14. Lee, J.C. et al. Immunopharmacology 47, 185–201 (2000).

    Article  CAS  Google Scholar 

Download references

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Rudd, C. MAPK p38: alternative and nonstressful in T cells. Nat Immunol 6, 368–370 (2005). https://doi.org/10.1038/ni0405-368

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