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Conceptualizing immune responsiveness

Communicating about and comprehending immune responses and immunity will be facilitated by greater attention to semantic precision and consistency and increased willingness to engage with the full dimensionality and quantitative nature of immunological phenomena.

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References

  1. Burnet, F.M. The Clonal Selection Theory of Acquired Immunity (Cambridge University Press, London, 1959).

    Google Scholar 

  2. Janeway, C.A., Jr. Immunol. Today 13, 11–16 (1992).

    Article  CAS  Google Scholar 

  3. Matzinger, P. Annu. Rev. Immunol. 12, 991–1045 (1994).

    Article  CAS  Google Scholar 

  4. Greenspan, N.S. Adv. Cancer Res. 80, 147–187 (2001).

    Article  CAS  Google Scholar 

  5. Ulloa, L. & Messmer, D. Cytokine Growth Factor Rev. published online 2 March 2006 (doi:10.1016/j.cytogfr.2006.01.003).

  6. Beauchamp, G.K., Yamazaki, K., Curran, M., Bard, J. & Boyse, E.A. Immunogenetics 39, 109–113 (1994).

    Article  CAS  Google Scholar 

  7. Koropatnick, T.A. et al. Science 306, 1186–1188 (2004).

    Article  CAS  Google Scholar 

  8. Nemazee, D., Gavin, A., Hoebe, K. & Beutler, B. Nature 441, 7091:E4 (2006).

    Article  CAS  Google Scholar 

  9. El-Sawy, T., Miura, M. & Fairchild, R. Am. J. Pathol. 165, 147–157 (2004).

    Article  CAS  Google Scholar 

  10. Alberts, B., Bray, D., Lewis, J., Raff, M. Roberts. K., & Watson, J.D. Molecular Biology of the Cell 2nd edn. 94 (Garland Publishing, New York and London, 1989).

    Google Scholar 

  11. Náray-Szabó, G . J. Mol. Recognit. 6, 205–210 (1993).

    Article  Google Scholar 

  12. Kosko, B. Fuzzy Thinking: The New Science of Fuzzy Logic (Hyperion, New York, 1993).

  13. Beckner, M. The Biological Way of Thought (University of California Press, Berkeley, California, 1968).

    Google Scholar 

  14. Hamers-Casterman, C. et al. Nature 363, 446–448 (1993).

    Article  CAS  Google Scholar 

  15. Magor, K.E., Warr, G.W., Middleton, D., Wilson, M.R. & Higgins, D.A. J. Immunol. 149, 2627–2633 (1992).

    CAS  PubMed  Google Scholar 

  16. Mayr, E. Science 134, 1501–1506 (1961).

    Article  CAS  Google Scholar 

  17. Greenspan, N.S. Humanist. Math. Network J. [online] http://www2.hmc.edu/www_common/hmnj/ (2004).

  18. Mayr, E. Toward a New Philosophy of Biology: Observations of an Evolutionist 196–214 (Belknap, Cambridge, Massachusetts, 1988).

    Google Scholar 

  19. Ross, L. Advances in Experimental Social Psychology Vol. 10 (ed. Berkowitz, L.) 174–214 (Academic, New York, 1977).

    Google Scholar 

  20. Greenspan, N.S. Bull. Inst. Pasteur 90, 267–279 (1992).

    Google Scholar 

  21. Sporn, M.B. Kidney Int. 51, 1352–1354 (1997).

    Article  CAS  Google Scholar 

  22. Lewontin, R.C. Science 291, 1263–1264 (2001).

    Article  CAS  Google Scholar 

  23. Pace, N.R. Nature 441, 289 (2006).

    Article  CAS  Google Scholar 

  24. Greenspan, N.S. Scientist 16, 12 (2002).

    Google Scholar 

Download references

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Greenspan, N. Conceptualizing immune responsiveness. Nat Immunol 8, 5–7 (2007). https://doi.org/10.1038/ni0107-5

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