Historical accounts of important experiments in Immunology provide insight and continuity to present areas of research. Jacques F.A.P. Miller inaugurates the Essay format with his seminal work on the thymus.
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04 January 2006
PDF only, note added to html version
Notes
NOTE: In the print version of this essay and the version initially published online, the second sentence of the sixth paragraph is incorrect. It should end “…many questions remained unexamined and unanswered.” The error has been corrected in the PDF version of the essay. This correction has been appended to the PDF version.
References
Gross, L. Pathogenic properties and “vertical” transmission of the mouse leukemia agent. Proc. Soc. Exp. Biol. Med. 78, 342–348 (1951).
Miller, J.F.A.P. Role of the thymus in murine leukaemia. Nature 183, 1069 (1959).
Miller, J.F.A.P. Fate of subcutaneous thymus grafts in thymectomized mice inoculated with leukaemic filtrates. Nature 184, 1809–1810 (1959).
Miller, J.F.A.P. Recovery of leukaemogenic agent from non-leukaemic tissues of thymectomized mice. Nature 187, 703 (1960).
Miller, J.F.A.P. Analysis of the thymus influence in leukaemogenesis. Nature 191, 248–249 (1961).
Gowans, J.L., McGregor, D.D., Cowen, D.M. & Ford, C.E. Initiation of immune responses by small lymphocytes. Nature 196, 651–653 (1962).
Billingham, R.E., Brent, L. & Medawar, P.B. “Actively acquired tolerance” of foreign cells. Nature 172, 603–606 (1953).
Miller, J.F.A.P. Immunological function of the thymus. Lancet 2, 748–749 (1961).
Miller, J.F.A.P. Effect of neonatal thymectomy on the immunological responsiveness of the mouse. Proc. Roy. Soc. 156B, 415–428 (1962).
Miller, J.F.A.P. Immunological significance of the thymus of the adult mouse. Nature 195, 1318–1319 (1962).
Miller, J.F.A.P., Grant, G.A. & Roe, F.J.C. Effect of thymectomy on the induction of skin tumours by 3,4-benzopyrene. Nature 199, 920–922 (1963).
Miller, J.F.A.P., Law, L.W. & Ting, R.C. Influence of thymectomy on tumor induction by polyoma virus in C57BL mice. Proc. Soc. Exp. Biol. Med, 116, 323–327 (1964).
Law, L.W., Dunn, T.B., Trainin, N. & Levey, R.H. in The Wistar Institute Symposium 105–117 (The Wistar Institute Press, Philadelphia, 1962).
McIntire, K.R., Sell, S & Miller, J.F.A.P. Pathogenesis of the post-neonatal thymectomy wasting syndrome. Nature 204, 151–155 (1964).
Miller, J.F.A.P. & Mitchell, G.F. The thymus and the precursors of antigen-reactive cells. Nature 216, 659–663 (1967).
Mitchell, G.F & Miller, J.F.A.P. Immunological activity of thymus and thoracic duct lymphocytes. Proc. Nat. Acad. Sci. USA 59, 296–303 (1968).
Miller, J.F.A.P. & Mitchell, G.F. Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes. J. Exp. Med. 128, 821–837 (1968).
Mitchell, G.F & Miller, J.F.A.P. Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes. J. Exp. Med 128, 821–837 (1968).
Cheers, C. & Miller, J.F.A.P. Cell to cell interaction in the immune response. IX. Regulation of hapten-specific antibody class by carrier priming. J. Exp. Med. 136, 1661–1665 (1972).
Burnet, F.M. in Genes, Dreams and Realities (MTP, Oxford, 1971).
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Miller, J. Vestigial no more. Nat Immunol 7, 3–5 (2006). https://doi.org/10.1038/ni0106-3
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DOI: https://doi.org/10.1038/ni0106-3
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