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Thymic IL-7 signaling goes beyond survival

Nature Immunology volume 16, pages 337–338 (2015)Cite this article

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Interleukin 7 (IL-7) promotes the self-renewing ability of CD4− CD8− double-negative thymocytes by both supporting cell growth and repressing rearrangements of the locus encoding the T cell antigen receptor (TCR).

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Figure 1: IL-7 signaling optimizes the proliferation of DN thymocytes.

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  1. Division of Infection and Immunity, Benedict Seddon is at the Institute of Immunity and Transplantation, University College London, Royal Free Hospital, London, UK.,

    Benedict Seddon

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  1. Benedict Seddon
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Correspondence to Benedict Seddon.

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Seddon, B. Thymic IL-7 signaling goes beyond survival. Nat Immunol 16, 337–338 (2015). https://doi.org/10.1038/ni.3128

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