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The lymph node filter revealed

Stromal cells in the subcapsular sinus of the lymph node 'decide' which cells and molecules are allowed access to the deeper parenchyma. The glycoprotein PLVAP is a crucial component of this selector function.

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Figure 1: A PLVAP diaphragm in LECs.

Katie Vicari/Nature Publishing Group

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Correspondence to Michael Sixt.

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Hons, M., Sixt, M. The lymph node filter revealed. Nat Immunol 16, 338–340 (2015). https://doi.org/10.1038/ni.3126

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