Hyperactivity of a branch of the unfolded protein response in CD8α+ dendritic cells degrades endoplasmic reticulum–associated mRNAs, which leads to a defect in the cross-presentation of dead cell–derived antigens.
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Subramanian, M., Tabas, I. A new RIDDle in DC-mediated cross-presentation. Nat Immunol 15, 213–215 (2014). https://doi.org/10.1038/ni.2826
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DOI: https://doi.org/10.1038/ni.2826
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