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Don't move: LRRK2 arrests NFAT in the cytoplasm

Nature Immunology volume 12, pages 1029–1030 (2011)Cite this article

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The kinase LRRK2 is a risk factor for inflammatory bowel disease. New data show that LRRK2 blocks the transport of NFAT to the nucleus and that LRRK2 deficiency results in enhanced susceptibility to experimental colitis in mice.

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Figure 1: LRRK2 blocks the translocation of NFAT to the nucleus, and the allele frequency of rs3761863 is high worldwide.

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Author notes

  1. Luis B. Barreiro is in the Department of Pediatrics, Faculty of Medicine, Sainte-Justine Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.

Authors and Affiliations

  1. Bana Jabri is in the Department of Medicine, Department of Pathology and Department of Pediatrics, University of Chicago, Chicago, Illinois, USA.,

    Bana Jabri & Luis B Barreiro

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  1. Bana Jabri
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  2. Luis B Barreiro
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Correspondence to Bana Jabri.

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The authors declare no competing financial interests.

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Jabri, B., Barreiro, L. Don't move: LRRK2 arrests NFAT in the cytoplasm. Nat Immunol 12, 1029–1030 (2011). https://doi.org/10.1038/ni.2139

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