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Distinction between Two Types of Beta-Thalassaemia by Inducibility of the Cell-free Synthesis of Beta-Chains by Nonthalassaemic Soluble Fraction

Nature New Biology volume 239, pages 234–235 (1972)Cite this article

Abstract

β-THALASSAEMIA is a hereditary anaemia in which the β-chains of haemoglobin, though structurally normal, are synthesized abnormally slowly. The β-thalassaemia of the Ferrara region of Italy is distinguished in the homozygote by β-chain synthesis which is not merely reduced but completely absent. It has recently been reported that, in a cell-free system, ribosomes from such subjects do not make β-chains in the presence of their own supernatant but do when nonthalassaemic supernatant is substituted1. It was shown that this effect was due to a factor other than mRNA.

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References

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Authors and Affiliations

  1. Departments of Medicine and Pediatrics and Division of Genetics, University of Rochester School of Medicine, Rochester, New York, 14642

    P. T. ROWLEY & BARBARA KOSCIOLEK

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  1. P. T. ROWLEY
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  2. BARBARA KOSCIOLEK
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ROWLEY, P., KOSCIOLEK, B. Distinction between Two Types of Beta-Thalassaemia by Inducibility of the Cell-free Synthesis of Beta-Chains by Nonthalassaemic Soluble Fraction. Nature New Biology 239, 234–235 (1972). https://doi.org/10.1038/newbio239234a0

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