Abstract
Wood and colleagues present the results from a randomized phase III trial comparing adjuvant vitespen therapy with observation alone following nephrectomy for the treatment of kidney cancer. The primary end point, recurrence-free survival, was similar in both groups. Although patients with early-stage kidney cancer tended to have improved recurrence-free survival compared with the observation group, the difference was not significant. Results for the secondary end point, overall survival, were not mature, and patients continue to be followed up. Five other randomized trials of adjuvant immunotherapy for kidney cancer have been published; all trials using cytokines failed to improve recurrence-free survival and overall survival, and only an autologous tumor cell vaccine (Reniale®; LipoNova AG, Hannover, Germany) demonstrated a significant improvement in recurrence-free survival and overall survival. Reniale® is not, however, approved for clinical use.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Wood C et al. (2008) An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised phase III trial. Lancet 372: 92–93
Keilholz U et al. (2002) Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy. J Immunother 25: 97–138
Das T et al. (2008) Renal cell carcinoma tumors induce T cell apoptosis through receptor-dependent and receptor-independent pathways. J Immunol 180: 4687–4696
Romero JM et al. (2006) Analysis of the expression of HLA class I, proinflammatory cytokines and chemokines in primary tumors from patients with localized and metastatic renal cell carcinoma. Tissue Antigens 68: 303–310
Doehn C and Jocham D (2004) Vaccination immunotherapy—an update. Scand J Surg 93: 163–169
Jocham D et al. (2004) Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: phase III, randomised controlled trial. Lancet 363: 594–599
Doehn C et al. (2007) An adjuvant vaccination with Reniale® prolongs survival in patients with renal cell carcinoma following radical nephrectomy: Secondary analysis of a multicenter phase-III trial [abstract #500]. J Urol 177 (Suppl): 167
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
Both Christian Doehn and Dieter Jocham declared that they have received honoraria and grant/research support from LipoNova AG.
Rights and permissions
About this article
Cite this article
Doehn, C., Jocham, D. Does adjuvant vitespen prevent recurrence in patients with locally advanced kidney cancer?. Nat Rev Urol 5, 644–645 (2008). https://doi.org/10.1038/ncpuro1256
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncpuro1256