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Interferon β adenoviral gene therapy in a patient with ovarian cancer

Nature Clinical Practice Oncology volume 3, pages 633–639 (2006)Cite this article

Abstract

Background A 47-year-old woman with a history of ovarian cancer and a 6-year disease-free remission presented with dyspnea and increased abdominal girth. The patient was found to have ascites and a large left pleural effusion, both of which contained malignant cells consistent with recurrent ovarian cancer. Her disease progressed despite treatment with chemotherapeutic and hormonal agents. She was then enrolled in a phase I clinical trial of adenoviral-mediated interferon β gene therapy.

Investigations Abdominal and chest CT scans, 2-[18F]fluoro-2-deoxyglucose PET scan, viral cultures, interferon cytokine analysis, immunophenotyping, and tumor cytotoxicity analyses.

Diagnosis Stage IV ovarian cancer with malignant ascites and pleural effusion.

Management Tunneled pleural catheter and intrapleural adenoviral-mediated interferon β gene therapy.

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Figure 1: Evaluation of tumor response to therapy.
Figure 2: Cellular composition of pleural fluid lymphocytes before and after treatment.
Figure 3: Evaluation of tumor-specific cellular immune response to therapy.

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Acknowledgements

This work was supported by National Institutes of Health grant P01 CA 66726.

Author information

Authors and Affiliations

  1. Associate Professor of Medicine, the Thoracic Oncology Research Laboratory,

    Daniel H Sterman

  2. pulmonary medicine, the Thoracic Oncology Research Laboratory,

    Colin T Gillespie & Andrew Haas

  3. Senior Research Investigator, the Thoracic Oncology Research Laboratory,

    Jing Sun

  4. Professor of Surgery, the Thoracic Oncology Research Laboratory,

    Larry R Kaiser

  5. Professor of Medicine, the Thoracic Oncology Research Laboratory,

    Steven M Albelda

  6. Research Assistant Professor, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA

    Richard G Carroll

  7. Instructor in Pediatrics, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA

    Christina M Coughlin

  8. Research Specialist, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA

    Elaina M Lord

  9. Research Nurse, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA

    Adri Recio

  10. Associate Professor of Surgery, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA

    George Coukos

  11. Professor of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA

    Carl H June

  12. Assistant Professor of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA

    Robert H Vonderheide

Authors
  1. Daniel H Sterman
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  2. Colin T Gillespie
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  3. Richard G Carroll
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  4. Christina M Coughlin
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  5. Elaina M Lord
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  6. Jing Sun
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  8. Adri Recio
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  10. George Coukos
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  11. Carl H June
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  12. Steven M Albelda
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Corresponding author

Correspondence to Robert H Vonderheide.

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The authors declare no competing financial interests.

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Sterman, D., Gillespie, C., Carroll, R. et al. Interferon β adenoviral gene therapy in a patient with ovarian cancer. Nat Rev Clin Oncol 3, 633–639 (2006). https://doi.org/10.1038/ncponc0658

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