The final steps in the biosynthetic pathway to the morphine alkaloids have been revealed with the characterization of two key enzymes. In addition to the widely exploited parent compound, these new O-demethylases control metabolic flux to pharmaceutically useful opioid precursors.
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Dimise, E., Bruner, S. Unmasking morphine. Nat Chem Biol 6, 251–252 (2010). https://doi.org/10.1038/nchembio.334
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DOI: https://doi.org/10.1038/nchembio.334
