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Protein engineering

Beating the odds

Recently developed advanced microfluidics-based systems have outperformed known screening tools with respect to throughput, flexibility, sensitivity and tricks for hit recovery. This has enabled the discovery of novel and improved proteins from random mutagenesis libraries or metagenome-based sources.

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Figure 1: Principle of the two microfluidic-based ultra-high-throughput systems.

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Correspondence to Uwe T Bornscheuer.

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Bornscheuer, U. Beating the odds. Nat Chem Biol 12, 54–55 (2016). https://doi.org/10.1038/nchembio.1989

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