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Enzyme regulation

A thiol switch opens the gate

Nature Chemical Biology volume 11, pages 4–5 (2015)Cite this article

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AAA+ proteases are quality control machineries consisting of substrate-binding ATPase modules for protein unfolding and a proteolytic chamber. New research now shows a redox switch in the Escherichia coli Lon protease that controls this process, widening the exit pore and activating proteolysis during transition from anaerobic to aerobic environments.

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Figure 1: Domain structure of E. coli Lon and mechanism of redox control for ATP-dependent proteolysis.

References

  1. Sauer, R.T. & Baker, T.A. Annu. Rev. Biochem. 80, 587–612 (2011).

    Article  CAS  Google Scholar 

  2. Neuwald, A.F., Aravind, L., Spouge, J.L. & Koonin, E.V. Genome Res. 9, 27–43 (1999).

    CAS  PubMed  Google Scholar 

  3. Van Melderen, L. & Aertsen, A. Res. Microbiol. 160, 645–651 (2009).

    Article  CAS  Google Scholar 

  4. Nishii, W. et al. Nat. Chem. Biol. 10.1038/nchembio.1688 (10 November 2014).

  5. Antelmann, H. & Helmann, J.D. Antioxid. Redox Signal. 14, 1049–1063 (2011).

    Article  CAS  Google Scholar 

  6. Newberry, K.J., Fuangthong, M., Panmanee, W., Mongkolsuk, S. & Brennan, R.G. Mol. Cell 28, 652–664 (2007).

    Article  CAS  Google Scholar 

  7. Choi, H. et al. Cell 105, 103–113 (2001).

    Article  CAS  Google Scholar 

  8. Jakob, U., Muse, W., Eser, M. & Bardwell, J.C. Cell 96, 341–352 (1999).

    Article  CAS  Google Scholar 

  9. Voth, W. et al. Mol. Cell 56, 116–127 (2014).

    Article  CAS  Google Scholar 

  10. Zhang, Y. & Zuber, P. J. Bacteriol. 186, 7669–7680 (2007).

    Article  Google Scholar 

Download references

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  1. Haike Antelmann is at the Institute for Microbiology, Ernst-Moritz-Arndt-University of Greifswald, Greifswald, Germany.,

    Haike Antelmann

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  1. Haike Antelmann
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Correspondence to Haike Antelmann.

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Antelmann, H. A thiol switch opens the gate. Nat Chem Biol 11, 4–5 (2015). https://doi.org/10.1038/nchembio.1698

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