The targeted release of bioactive molecules to diseased tissues has the potential to improve therapeutic efficacy, but not all drugs contain a free functional group that can be easily attached to an antibody. Now, a linker technology has been developed to enable the traceless release of tertiary and heteroaryl amine-containing drugs.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Chudasama, V., Maruani, A. & Caddick, S. Nat. Chem. 8, 114–119 (2016).
Rodrigues, T., Reker, D., Schneider, P. & Schneider, G. Nat. Chem. 8, 531–541 (2016).
Staben, L. R. et al. Nat. Chem. 8, 1112–1119 (2016).
Burke, P. J. et al. Mol. Cancer Ther. 15, 938–945 (2016).
Lehar, S. M. et al. Nature 527, 323–328 (2015).
Baell, J. B. & Holloway, G. A. J. Med. Chem. 53, 2719–2740 (2010).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Rodrigues, T., Bernardes, G. The missing link. Nature Chem 8, 1088–1090 (2016). https://doi.org/10.1038/nchem.2685
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.2685
This article is cited by
-
Theranostic applications of smart nanomedicines for tumor-targeted chemotherapy: a review
Environmental Chemistry Letters (2020)
-
Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents
Nature Protocols (2019)