A new click-style reaction based on a strain-release amination strategy has been developed. This approach can be used to append small, strained ring systems onto a core scaffold.
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Milligan, J., Wipf, P. Straining to react. Nature Chem 8, 296–297 (2016). https://doi.org/10.1038/nchem.2485
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DOI: https://doi.org/10.1038/nchem.2485