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Implantable synthetic organoid matrices for intestinal regeneration

Nature Cell Biology volume 19, pages 1307–1308 (2017)Cite this article

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Organoids are a powerful tool to study both physiological and disease processes. A completely synthetic matrix assembled from exchangeable modular parts has been developed and not only supports proliferation of human intestinal organoids derived from pluripotent embryonic stem cells, but also augments subsequent ad vivo implantation into injured murine colon.

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Figure 1: Synthetic matrices augment ad vivo implantation of human intestinal organoids.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, 63110, Missouri, USA

    Jeffrey W. Brown & Jason C. Mills

  2. Department of Developmental Biology and the Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, 63110, Missouri, USA

    Jason C. Mills

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  1. Jeffrey W. Brown
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  2. Jason C. Mills
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Correspondence to Jason C. Mills.

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Brown, J., Mills, J. Implantable synthetic organoid matrices for intestinal regeneration. Nat Cell Biol 19, 1307–1308 (2017). https://doi.org/10.1038/ncb3635

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