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On keeping the right ER size

Nature Cell Biology volume 18, pages 1118–1119 (2016)Cite this article

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The endoplasmic reticulum (ER) is the largest membrane-bound organelle in cells, and its size needs to be carefully controlled. Downsizing the ER by autophagy is now shown to involve Sec62, a protein that also helps to build up the organelle. This link suggests a molecular switch for ER size control.

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Figure 1: Sec62 coordinates ER biogenesis and degradation.

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  1. Sebastian Schuck is at the CellNetworks Cluster of Excellence and Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Heidelberg University, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany,

    Sebastian Schuck

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  1. Sebastian Schuck
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Correspondence to Sebastian Schuck.

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Schuck, S. On keeping the right ER size. Nat Cell Biol 18, 1118–1119 (2016). https://doi.org/10.1038/ncb3430

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