Abstract
We present evidence that acrylate is an intermediate in the direct reduction of lactate to propionate in Clostridium propionicum. In the presence of 3–butynoic acid, an inhibitor of acyl–CoA dehydrogenase, acrylate was formed from D–lactate and detected by gas–liquid chromatography and mass spectrometry. This represents the first direct demonstration of acrylate accumulation from lactate in C. propionicum.
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Akedo, M., Cooney, C. & Sinskey, A. Direct Demonstration of Lactate–Acrylate Interconversion in Clostridium Propionicum. Nat Biotechnol 1, 791–794 (1983). https://doi.org/10.1038/nbt1183-791
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DOI: https://doi.org/10.1038/nbt1183-791
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