Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Simple recipe for blocking ion channels

Nature Biotechnology volume 23, pages 1234–1235 (2005)Cite this article

Ion channels can be inshibited by polyclonal antibodies targeted to a specific extracellular loop.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: E3 targeting of six-transmembrane-domain ion channels.

Bob Crimi

References

  1. Xu, S.-H. et al. Nat. Biotechnol. 23, 1289–1293 (2005).

    Article  CAS  Google Scholar 

  2. Dallas, M. Deuchars, S.A. & Deuchars, J.J. Neurosci. Methods 146, 133–148 (2005)

    Article  CAS  Google Scholar 

  3. Choe, S. Nat. Rev. Neurosci. 3, 115–121 (2002).

    Article  CAS  Google Scholar 

  4. Beech, D.J. Clin Exp Pharmacol Physiol. 2005 32(8): 597–603 (2005)

    Article  Google Scholar 

  5. Zhou, B.Y., Ma, W. & Huang, X.Y. J. Gen. Physiol. 111, 555–563 (1998).

    Article  CAS  Google Scholar 

  6. Xu S.Z. & Beech, D.J. Circ. Res. 88, 84–87, (2001).

    Article  CAS  Google Scholar 

  7. Rosado, J.A. Brownlow, S.L. & Sage, S.O. J. Biol. Chem. 277, 42157–42163 (2002)

    Article  CAS  Google Scholar 

  8. Clapham, D. Nature 426, 517–524 (2003).

    Article  CAS  Google Scholar 

  9. Guderman, T. & Flockerzi, V. Naunyn-Schmied. Arch. Pharm. 371, 325–333 (2005).

    Article  Google Scholar 

  10. Rami, H.K. et al. Bioorg. & Med. Chem. Lett. 14, 3631–3634 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurology and GI Center for Excellence in Drug Discovery (N&GI CEDD), GlaxoSmithKline Research and Development Ltd., New Frontiers Science Park (North), Harlow, Essex, CM19 5AW, UK

    Christopher D Benham

Authors
  1. Christopher D Benham
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Benham, C. Simple recipe for blocking ion channels. Nat Biotechnol 23, 1234–1235 (2005). https://doi.org/10.1038/nbt1005-1234

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt1005-1234

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing