Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The worm turns for antimicrobial discovery

High-throughput screening using an in vivo infection model identifies nontraditional antimicrobials.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Compounds that promote survival of Caenorhabditis elegans after persistent infection with Enterococcus faecalis can either prevent persistence of the pathogen in the intestine or enable the host to tolerate chronic innocuous intestinal colonization.

Katie Ris

References

  1. Brown, E.D. & Wright, G.D. Chem. Rev. 105, 759–774 (2005).

    Article  CAS  Google Scholar 

  2. Moy, T.I. et al. Proc. Natl. Acad. Sci. USA 103, 10414–10419 (2006).

    Article  CAS  Google Scholar 

  3. Hung, D.T., Shakhnovich, E.A., Pierson, E & Mekalanos, J.J. Science 310, 670–674 (2005).

    Article  CAS  Google Scholar 

  4. Kauppi, A.M et al. Chem. Biol. 10, 241–249 (2003).

    Article  CAS  Google Scholar 

  5. Gauthier, A. et al. Antimicrob. Agents Chemother. 49, 4101–4109 (2005).

    Article  CAS  Google Scholar 

  6. Nordfelth, R. et al. Infect. Immun. 73, 3104–3114 (2005).

    Article  CAS  Google Scholar 

  7. Li, X. et al. Chem. Biol. 11, 1423–1430 (2004).

    Article  CAS  Google Scholar 

  8. Wang, J. et al. Nature 441, 358–361 (2006).

    Article  CAS  Google Scholar 

  9. Kwok, T.C.Y. et al. Nature 441, 91–95 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bhavsar, A., Brown, E. The worm turns for antimicrobial discovery. Nat Biotechnol 24, 1098–1100 (2006). https://doi.org/10.1038/nbt0906-1098

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0906-1098

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing