Cas9 can induce extensive on-target damage, including large deletions, inversions, and insertions.
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J.-S.K. is a cofounder of and holds stock in ToolGen, Inc., a company focused on therapeutic genome editing.
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Lee, H., Kim, JS. Unexpected CRISPR on-target effects. Nat Biotechnol 36, 703–704 (2018). https://doi.org/10.1038/nbt.4207
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DOI: https://doi.org/10.1038/nbt.4207
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