Is it time to reassess the 14-day rule for human embryo research?
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Change history
10 November 2017
In the version of this article initially published, J.E. Lunshof's affiliation was given as “Center for Bioethics, Harvard Medical School, Boston, Massachusetts, USA”; the affiliation should have included her main affiliation at the University of Groningen and read, “Department of Genetics, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands, and Department of Genetics, Church laboratory, Harvard Medical School, Boston, Massachusetts, USA.” In addition, “Divinity School, University of Chicago,” should be “University of Chicago Divinity School.” The errors have been corrected in the HTML and PDF versions of the article.
References
Warnock, M. et al. Report of the Committee of Inquiry into Human Fertilisation and Embryology (Her Majesty's Stationery Office, London, UK, 1984).
Shahbazi, M.N. Self-organization of the human embryo in the absence of maternal tissues. Nat. Cell. Biol. 18, 700–708 (2016).
Deglincerti, A. et al. Self-organization of the in vitro attached human embryo. Nature 533, 251–254 (2016).
Bedzhov, I. & Zernicka-Goetz, M. Self-organizing properties of mouse pluripotent cells initiate morphogenesis upon implantation. Cell 156, 1032–1044 (2014).
Bedzhov, I., Leung, C.Y., Bialecka, M. & Zernicka-Goetz, M. In vitro culture of mouse blastocysts beyond the implantation stages. Nat. Protoc. 9, 2732–2739 (2014).
Partridge, E. et al. An extra-uterine system to physiologically support the extreme premature lamb. Nat. Commun. 8, 15112 (2017).
Nuffield Council on Bioethics. Human Embryo Culture http://nuffieldbioethics.org/wp-content/uploads/Human-Embryo-Culture-web-FINAL.pdf (Nuffield Council on Bioethics, 2017).
Harrison, S.E., Sozen, B., Christodoulou, N., Kyprianou, C. & Zernicka-Goetz, M. Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro. Science 356, https://dx.doi.org/10.1126/science.aal1810 (2017).
Hammond-Browning, N. Ethics, embryos, and evidence: a look back at Warnock. Med. Law Rev. 23, 588–619 (2015).
Cavaliere, G. A 14-limit for bioethics: the debate over human embryo research. BMC Med. Eth. https://dx.doi.org/10.1186/s12910-017-0198-5 (2017).
Warnock, M. Moral thinking and government policy: the Warnock Committee on Human Embryology. Milbank Mem. Fund Q. Health Soc. 63, 504–522 (1985).
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Hurlbut, J., Hyun, I., Levine, A. et al. Revisiting the Warnock rule. Nat Biotechnol 35, 1029–1042 (2017). https://doi.org/10.1038/nbt.4015
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DOI: https://doi.org/10.1038/nbt.4015