Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

Massively parallel interrogation of the effects of gene expression levels on fitness

Keren, L. et al. Cell 166, 1282–1294 (2016)

Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution

Corces, M.R. et al. Nat. Genet. doi:10.1038/ng.3646 (2016)

Stable long-term chronic brain mapping at the single-neuron level

Fu, T.M. et al. Nat. Methods doi:10.1038/nmeth.3969 (2016)

Rewriting yeast central carbon metabolism for industrial isoprenoid production

Meadows, A.L. et al. Nature doi:10.1038/nature19769 (2016)

Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

Waldorf, K.M.A. et al. Nat. Med. doi:10.1038/nm.4193 (2016)

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

Xu, M. et al. Nat. Med. doi:10.1038/nm.4184 (2016)