Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

A general framework for estimating the relative pathogenicity of human genetic variants

Kircher, M. et al. Nat. Genet. doi:10.1038/ng.2892 (2 February 2014)

Mapping sensory circuits by anterograde transsynaptic transfer of recombinant rabies virus

Zampieri, N. et al. Neuron doi:10.1016/j.neuron.2013.12.033 (30 January 2014)

In vivo discovery of immunotherapy targets in the tumour microenvironment

Zhou, P. et al. Nature 506, 52–57 (2014)

Stimulus-triggered fate conversion of somatic cells into pluripotency

Obokata, H. et al. Nature 505, 641–647 (2014)

Bidirectional developmental potential in reprogrammed cells with acquired pluripotency

Obokata, H. et al. Nature 505, 676–680 (2014)

Cancer cell profiling by barcoding allows multiplexed protein analysis in fine-needle aspirates

Ullal, A.V. et al. Sci. Transl. Med. 6, 219ra9 (2014)