When human blastocysts are cultured in vitro to derive embryonic stem cells, they undergo profound molecular changes that alter their identity.
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Pribluda, A., Hanna, J. Tracing the genesis of human embryonic stem cells. Nat Biotechnol 30, 247–249 (2012). https://doi.org/10.1038/nbt.2139
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DOI: https://doi.org/10.1038/nbt.2139