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Metabolism

Energy sensing through a sugar diphosphate

The molecule fructose-1,6-bisphosphate, which is produced during glucose metabolism, has been shown to mediate cellular sensing of glucose deprivation through an unexpected mechanism. See Letter p.112

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Figure 1: Activating AMPK.

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Correspondence to Bruce E. Kemp.

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Kemp, B., Oakhill, J. Energy sensing through a sugar diphosphate. Nature 548, 36–37 (2017). https://doi.org/10.1038/nature23099

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