If a tumour outgrows its blood supply, oxygen levels in its cells decrease. It emerges that this change can alter gene expression by limiting the activity of TET enzymes, which remove methyl groups from DNA. See Article p.63
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Ye, D., Xiong, Y. Suffocation of gene expression. Nature 537, 42–43 (2016). https://doi.org/10.1038/nature19426
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DOI: https://doi.org/10.1038/nature19426
