Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Parkinson's disease

Disorder in the court

The native structure of the protein α-synuclein, which is implicated in Parkinson's disease, is controversial. In-cell nuclear magnetic resonance now shows that it remains disordered when loaded into living cells. See Article p.45

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Structure of a disordered protein in living cells.

Notes

  1. See all news & views

References

  1. Fauvet, B. et al. J. Biol. Chem. 287, 15345–15364 (2012).

    Article  CAS  Google Scholar 

  2. Bartels, T., Choi, J. G. & Selkoe, D. J. Nature 477, 107–110 (2011).

    Article  ADS  CAS  Google Scholar 

  3. Dettmer, U. et al. Nature Commun. 6, 7314 (2015).

    Article  ADS  Google Scholar 

  4. Alderson, T. R. & Markley, J. L. Intrins. Disord. Proteins 1, 18–39 (2013).

    Article  Google Scholar 

  5. Theillet, F.-X. et al. Nature 530, 45–50 (2016).

    Article  ADS  CAS  Google Scholar 

  6. Sakakibara, D. et al. Nature 458, 102–105 (2009).

    Article  ADS  CAS  Google Scholar 

  7. Freedberg, D. I. & Selenko, P. Annu. Rev. Biophys. 43, 171–192 (2014).

    Article  CAS  Google Scholar 

  8. Lashuel, H. A., Overk, C. R., Oueslati, A. & Masliah, E. Nature Rev. Neurosci. 14, 38–48 (2013).

    Article  CAS  Google Scholar 

  9. Burré, J. et al. Science 329, 1663–1667 (2010).

    Article  ADS  Google Scholar 

  10. Luth, E. S., Bartels, T., Dettmer, U., Kim, N. C. & Selkoe, D. J. Biochemistry 54, 279–292 (2015).

    Article  CAS  Google Scholar 

  11. Burré, J., Sharma, M. & Südhof, T. C. Proc. Natl Acad. Sci. USA 111, E4274–E4283 (2014).

    Article  ADS  Google Scholar 

  12. Binolfi, A. et al. Nature Commun. http://dx.doi/10.1038/ncomms10251 (2016).

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to T. Reid Alderson or Ad Bax.

Related links

Related links

Related links in Nature Research

Parkinson's disease: Crystals of a toxic core

Structural biology: Inside the living cell

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Alderson, T., Bax, A. Disorder in the court. Nature 530, 38–39 (2016). https://doi.org/10.1038/nature16871

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature16871

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing