In this Letter, we reported that Hmga2 promotes lung cancer progression in mouse and human cells by operating as a competing endogenous RNA for the let-7 microRNA family. It has been brought to our attention that the cell lines used in the RNA sequencing (RNA-seq) experiment presented in Extended Data Fig. 4 of the Letter cannot be those specified in the figure legend. Moreover, these data cannot generate the Sylamer plots presented in this figure. The cell line substitution also casts doubt on which cells were used for experiments presented elsewhere in the paper. Although replication of other experiments in the Letter have not uncovered any further inconsistencies, given this uncertainty and the clear issues with Extended Data Fig. 4, we think it prudent to retract the paper pending more thorough investigation. We apologize for any adverse consequences that this may have caused.
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The online version of the original article can be found at 10.1038/nature12785
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Kumar, M., Armenteros-Monterroso, E., East, P. et al. Retraction Note: HMGA2 functions as a competing endogenous RNA to promote lung cancer progression. Nature 523, 370 (2015). https://doi.org/10.1038/nature14551
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DOI: https://doi.org/10.1038/nature14551
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