HIV variants that have mutated to escape T-cell immune responses dominate the latent viral reservoir in most patients on antiretroviral therapy. This finding will need to guide therapeutic approaches targeting reactivated virus. See Letter p.381
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Picker, L., Lifson, J. Seeking ultimate victory. Nature 517, 281–282 (2015). https://doi.org/10.1038/nature14194
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DOI: https://doi.org/10.1038/nature14194