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Vitamin D receptor gene polymorphisms and plasma renin activity in essential hypertensive individuals

Journal of Human Hypertension volume 29, pages 483–487 (2015)Cite this article

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Abstract

Several studies analyzed 25-hydroxyvitamin D (25[OH]D) and blood pressure (BP) relationship with mixed results. Moreover, a relationship between the risk of hypertension and vitamin D receptor (VDR) gene polymorphisms, FokI and BsmI, was reported. This study was aimed to analyze these relationships in essential hypertensive (EH) patients. Seventy-one EH patients, 18–75 years old, were enrolled. Patients underwent clinical BP, 24-h ambulatory BP monitoring, 25[OH]D and plasma renin activity (PRA) evaluations. FokI and BsmI VDR polymorphisms were analyzed and compared with those of 72 healthy controls. In EH patients, the median 25[OH]D levels were lower than 30 ng ml−1. We found a significant negative correlation between 25[OH]D and 24-h systolic BP (r=−0.277, P=0.043). This correlation persisted in backward stepwise multivariate analyses (β=−0.337; P=0.022), after adjustment for age, gender, body mass index, glomerular filtration rate, and PRA. We did not observe statistically significant correlation between 25[OH]D and PRA. We compared the allelic frequencies and genotype distribution between patients and controls, and FokI and BsmI VDR polymorphisms were not associated either with hypertensive status or with PRA. Further wide studies are needed to clarify this relationship.

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References

  1. Dusso AS, Brown AJ, Slatopolsky E . Vitamin D. Am J Physiol Renal Physiol 2005; 289: F8–F28.

    Article  CAS  Google Scholar 

  2. Almirall J, Vaqueiro M, Baré ML, Anton E . Association of low serum 25-hydroxyvitamin D levels and high arterial blood pressure in the elderly. Nephrol Dial Transplant 2010; 25: 503–509.

    Article  CAS  Google Scholar 

  3. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP . 1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002; 110: 229–238.

    Article  CAS  Google Scholar 

  4. Hollis BW, Wagner CL, Drezner MK, Binkley NC . Circulating Vitamin D3 and 25-hydroxyvitamin D in Humans: An Important Tool to Define Adequate Nutritional Vitamin D Status. J Steroid Biochem Mol Biol 2007; 103 (3–5): 631–634.

    Article  CAS  Google Scholar 

  5. Holick MF . Vitamin D status: measurement, interpretation and clinical application. Ann Epidemiol 2009; 19 (2): 73–78.

    Article  Google Scholar 

  6. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B . Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006; 84 (1): 18–28.

    Article  CAS  Google Scholar 

  7. Holick MF . Vitamin D deficiency. N Engl J Med 2007; 357: 266–281.

    Article  CAS  Google Scholar 

  8. Holick MF . High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006; 81: 353–373.

    Article  CAS  Google Scholar 

  9. Malabanan A, Veronikis IE, Holick MF . Redefining vitamin D insufficiency. Lancet 1998; 351: 805–806.

    Article  CAS  Google Scholar 

  10. Thomas MK, Lloyd-Jones DM, Thadhani RI, Shaw AC, Deraska DJ, Kitch BT et al. Hypovitaminosis D in medical inpatients. N Engl J Med 1998; 338: 777–783.

    Article  CAS  Google Scholar 

  11. Muray S, Parisi E, Cardús A, Craver L, Fernández E . Influence of vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D on blood pressure in apparently healthy subjects. J Hypertens 2003; 21 (11): 2069–2075.

    Article  CAS  Google Scholar 

  12. Swapna N, Vamsi UM, Usha G, Padma T . Risk conferred by FokI polymorphism of vitamin D receptor (VDR) gene for essential hypertension. Indian J Hum Genet 2011; 17 (3): 201–206.

    Article  CAS  Google Scholar 

  13. Wang L, Ma J, Manson JE, Buring JE, Gaziano JM, Sesso HD . A prospective study of plasma vitamin D metabolites, vitamin D receptor gene polymorphisms, and risk of hypertension in men. Eur J Nutr 2013; 52 (7): 1771–1779.

    Article  CAS  Google Scholar 

  14. Lins LR, Nogueira LR, Lima RM, Gentil P, Oliveira RJ, Pereira RW . A multiplex single-base extension protocol for genotyping Cdx2, FokI, BsmI, ApaI, and TaqI polymorphisms of the vitamin D receptor gene. Genet Mol Res 2007; 6 (2): 316–324.

    CAS  PubMed  Google Scholar 

  15. Wang L, Chu A, Buring JE, Ridker PM, Chasman DI, Sesso HD . Common genetic variations in the vitamin D pathway in relation to Blood Pressure. Am J Hypertens 2014; 27 (11): 1387–1395.

    Article  CAS  Google Scholar 

  16. Feneis JF, Arora RR . Role of vitamin D in blood pressure homeostasis. Am J Ther 2010; 17 (6): e221–e229.

    Article  Google Scholar 

  17. Demir M, Günay T, Özmen G, Melek M . Relationship between vitamin d deficiency and nondipper hypertension. Clin Exp Hypertens 2013; 35 (1): 45–49.

    Article  CAS  Google Scholar 

  18. Moyano Peregrín C, López Rodríguez F, Castilla Castellano Mdel M . Vitamin D and hypertension. Med Clin (Barc) 2012; 138 (9): 397–401.

    Article  Google Scholar 

  19. Scragg R, Sowers M, Bell C . Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Examination Survey. Amer J Hypertens 2007; 20: 713–719.

    Article  CAS  Google Scholar 

  20. Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 2007; 49 (5): 1063–1069.

    Article  CAS  Google Scholar 

  21. Forman JP, Curhan GC, Taylor EN . Plasma 25-hydroxyvitamin D levels and risk of incident hypertension among young women. Hypertension 2008; 52 (5): 828–832.

    Article  CAS  Google Scholar 

  22. Snijder MB, Lips P, Seidell JC, Visser M, Deeg DJ, Dekker JM et al. Vitamin D status and parathyroid hormone levels in relation to blood pressure: a population-based study in older men and women. J Intern Med 2007; 261 (6): 558–565.

    Article  CAS  Google Scholar 

  23. Scragg R, Holdaway I, Singh V, Metcalf P, Baker J, Dryson E . Serum 25-hydroxycolecalciferol concentration in newly detected hypertension. Am J Hypertens 1995; 8: 429–432.

    Article  CAS  Google Scholar 

  24. Rueda S, Fernández-Fernández C, Romero F, Martínez de Osaba J, Vidal J . Vitamin D, PTH, and the metabolic syndrome in severely obese subjects. Obes Surg 2008; 18: 151–154.

    Article  Google Scholar 

  25. Levey A, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604–612.

    Article  Google Scholar 

  26. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D . A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130: 461–470.

    Article  CAS  Google Scholar 

  27. Forman JP, Williams JS, Fisher ND . Plasma 25-Hydroxyvitamin D and regulation of the renin-angiotensin system in humans. Hypertension 2010; 55: 1283–1288.

    Article  CAS  Google Scholar 

  28. Resnick LM, Müller FB, Laragh JH . Calcium-regulating hormones in essential hypertension. Relation to plasma renin activity and sodium metabolism. Ann Intern Med 1986; 105 (5): 649–654.

    Article  CAS  Google Scholar 

  29. Vaidya A, Sun B, Forman JP, Hopkins PN, Brown NJ, Kolatkar NS et al. The FOK1 Vitamin D receptor gene polymorphism is associated with plasma renin activity in caucasians. Clin Endocrinol (Oxf) 2011; 74 (6): 783–790.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Dipartimento Biomedico di Medicina Interna e Specialistica, Nephrology and Hypertension Unit, Università di Palermo, Palermo, Italy

    S Cottone, L Guarino, R Arsena, F Tornese, M Guarneri, C Guglielmo & G Mulè

  2. Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università di Palermo, Palermo, Italy,

    C Scazzone & A Bono

Authors
  1. S Cottone
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  2. L Guarino
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  3. R Arsena
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  4. C Scazzone
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  5. F Tornese
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  6. M Guarneri
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  7. C Guglielmo
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  9. G Mulè
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Correspondence to S Cottone.

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Cottone, S., Guarino, L., Arsena, R. et al. Vitamin D receptor gene polymorphisms and plasma renin activity in essential hypertensive individuals. J Hum Hypertens 29, 483–487 (2015). https://doi.org/10.1038/jhh.2014.113

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