Article PDF
References
Saijo Y, Yoshioka E, Fukui T, et al: Effects of the interaction of interleukin-6 −634C/G polymorphism and smoking on serum C-reactive protein concentrations. Hypertens Res 2007; 30: 593–599.
Koenig W, Sund M, Frohlich M, et al: C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation 1999; 99: 237–242.
Haverkate F, Thompson SG, Pyke SD, Gallimore JR, Pepys MB, European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group: Production of C-reactive protein and risk of coronary events in stable and unstable angina. Lancet 1997; 349: 462–466.
Fishman D, Faulds G, Jeffery R, et al: The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998; 102: 1369–1376.
Vickers MA, Green FR, Terry C, et al: Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein. Cardiovasc Res 2002; 53: 1029–1034.
Libra M, Signorelli SS, Bevelacqua Y, et al: Analysis of G(−174)C IL-6 polymorphism and plasma concentrations of inflammatory markers in patients with type 2 diabetes and peripheral arterial disease. J Clin Pathol 2006; 59: 211–215.
Sie MP, Sayed-Tabatabaei FA, Oei HH, et al: Interleukin 6 −174 G/C promoter polymorphism and risk of coronary heart disease: results from the Rotterdam Study and a meta-analysis. Arterioscler Thromb Vasc Biol 2006; 26: 212–217.
Ota N, Nakajima T, Nakazawa I, et al: A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density. J Hum Genet 2001; 46: 267–272.
Ferrari SL, Ahn-Luong L, Garnero P, Humphries SE, Greenspan SL : Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women. J Clin Endocrinol Metab 2003; 88: 255–259.
Jerrard-Dunne P, Sitzer M, Risley P, Buehler A, von Kegler S, Markus HS : Inflammatory gene load is associated with enhanced inflammation and early carotid atherosclerosis in smokers. Stroke 2004; 35: 2438–2443.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Iwamoto, S. Are Promoter Polymorphisms of Interleukin 6 Ready to Be Applied in Genetic Markers of Cardiovascular Diseases?. Hypertens Res 30, 575–576 (2007). https://doi.org/10.1291/hypres.30.575
Received:
Issue Date:
DOI: https://doi.org/10.1291/hypres.30.575