Abstract
Interferon regulatory factor 5 (IRF5) and signal transducer and activator of transcription 4 (STAT4) are shared susceptibility genes for various autoimmune diseases. In this study, we investigated whether these genes also contribute to susceptibility to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a Japanese population. A case–control study was carried out on IRF5 rs10954213 and STAT4 rs7574865 in 232 Japanese myeloperoxidase (MPO)–ANCA-positive AAV patients, including 177 microscopic polyangiitis and 710 healthy controls. IRF5 rs10954213G was significantly increased in MPO–ANCA-positive AAV (additive model, P=0.023, odds ratio=1.27, 95% confidence interval=1.03–1.57). The risk allele was previously shown to be associated with lower mRNA level of IRF5. On the other hand, significant association of STAT4 rs7574865T with AAV was not detected. These observations suggested that IRF5 may contribute to susceptibility to MPO–ANCA-positive AAV in a Japanese population.
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Acknowledgements
This work was supported by Grant-in-Aid for Scientific Research (B) (22390199), Grant-in-Aid for Challenging Exploratory Research (23659495) and Grant-in-Aid for Young Scientists (B) (23791101) from the Japan Society for the Promotion of Science (JSPS), Health and Labour Science Research Grants for Research on rare and intractable diseases from the Ministry of Health, Labour and Welfare of Japan, and the Japan Allergy Foundation and SENSHIN Medical Research Foundation.
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Kawasaki, A., Inoue, N., Ajimi, C. et al. Association of IRF5 polymorphism with MPO–ANCA-positive vasculitis in a Japanese population. Genes Immun 14, 527–529 (2013). https://doi.org/10.1038/gene.2013.45
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DOI: https://doi.org/10.1038/gene.2013.45
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