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The applied basic research of systemic lupus erythematosus based on the biological omics

Genes & Immunity volume 14, pages 133–146 (2013)Cite this article

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Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies directed against nuclear self-antigens and circulating immune complexes. This results in damages to various organs or systems, including skin, joints, kidneys and the central nervous system. Clinical manifestations of SLE could be diverse, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures and arthritis. The complicated pathogenesis and varied clinical symptoms of SLE pose great challenges in the diagnosis and monitoring of this disease. Unfortunately, the etiological factors and pathogenesis of SLE are still not completely understood. It is noteworthy that recent advances in our understanding of the biological omics and emerging technologies have been providing new tools in the analyses of SLE, such as genomics, epigenomics, transcriptomics, proteomics, metabolomics and so on. In this article, we summarize our current knowledge in this field for a better understanding of the pathogenesis, diagnosis and treatment for SLE.

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Acknowledgements

We thank Minglin Ou for helpful discussions. This work was supported by funds received from Guangxi Natural Science Foundation (no. 2012GXNSFDA053017), Guangxi Key Laboratory of Metabolic Diseases Research (no. 11-031-33 and 12-071-32) and Guilin Scientific Research and Technology Development Program (no. 20110119-8-1).

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  1. W Sui and X Hou: These authors contributed equally to the work.

Authors and Affiliations

  1. Nephrology Department, Guilin 181st Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Guilin, Guangxi, People’s Republic of China

    W Sui, X Hou, W Che, M Yang & Y Dai

  2. College of Life Science, Guangxi Normal University, Guilin, Guangxi, People’s Republic of China

    X Hou

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Sui, W., Hou, X., Che, W. et al. The applied basic research of systemic lupus erythematosus based on the biological omics. Genes Immun 14, 133–146 (2013). https://doi.org/10.1038/gene.2013.3

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