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TIM polymorphisms—genetics and function

Genes & Immunity volume 12, pages 595–604 (2011)Cite this article

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Abstract

The transmembrane immunoglobulin and mucin domain (TIM) family was identified more than a decade ago. Although the founding member of the family was first described in a rat model of ischemia–reperfusion injury, much of the recent interest in the TIM family members has focused on their potential roles in immunity. There are now a large number of genetic studies that have investigated the possible association of various TIM1 and TIM3 polymorphisms with different diseases. Here, we review this body of literature, and highlight some of the most interesting studies.

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Acknowledgements

Work on TIM proteins in the laboratory of LPK is supported by grants from the NIH (AI067544 and AI073748).

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Authors and Affiliations

  1. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    J Lee, B Phong & L P Kane

  2. Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    J Lee, B Phong & L P Kane

  3. Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    A M Egloff

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  1. J Lee
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  2. B Phong
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  4. L P Kane
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Correspondence to L P Kane.

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Lee, J., Phong, B., Egloff, A. et al. TIM polymorphisms—genetics and function. Genes Immun 12, 595–604 (2011). https://doi.org/10.1038/gene.2011.75

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