Abstract
We compared the distribution of the adhesive extracellular matrix glycoproteins thrombospondin and cellular fibronectin in epiretinal membranes. A total of nine membranes were investigated with immunohistochemical techniques. Thrombospondin and cellular fibronectin immunoreactivity were observed in seven of the specimens and immunostaining for the two glycoproteins was co-localised in four of the membranes. The findings indicate that thrombospondin contributes to the extracellular glycoprotein content of epiretinal membranes and is frequently co-distributed with cellular fibronectin in the tissue. As a consequence, thrombospondin may play a role in the assembly of the extracellular matrix of epiretinal membranes.
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Hiscott, P., Larkin, G., Robey, H. et al. Thrombospondin as a component of the extracellular matrix of epiretinal membranes: Comparisons with cellular fibronectin. Eye 6, 566–569 (1992). https://doi.org/10.1038/eye.1992.123
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DOI: https://doi.org/10.1038/eye.1992.123
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