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BAtCHing stem-like T cells during exhaustion

Nature Immunology volume 22, pages 274–276 (2021)Cite this article

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Long-term pathogen and tumor control as well as checkpoint immunotherapies rely on ‘stem-like’ CD8+ T cells. New results uncover BACH2 as a key regulator of this subpopulation and solve an important piece of the puzzle.

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Fig. 1: BACH2 promotes CD8+ T cell differentiation toward Texstem cells while antagonizing Texterm cell fates via epigenetic and transcriptional mechanisms in the early stage of chronic viral infection.

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Acknowledgements

We thank members of the Zúñiga laboratory for their valuable feedback. Research in the Zúñiga laboratory is supported by N.I.H. grants AI145314, AI081923, AI113923 and AI132122. L.L.-B. was partly supported by a ‘La Caixa’ fellowship for studies in North America and by the UCSD Frontiers of Innovation Scholars Program.

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  1. Lara Labarta-Bajo

    Present address: Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA

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  1. Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA

    Lara Labarta-Bajo & Elina I. Zúñiga

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  1. Lara Labarta-Bajo
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  2. Elina I. Zúñiga
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Correspondence to Elina I. Zúñiga.

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Labarta-Bajo, L., Zúñiga, E.I. BAtCHing stem-like T cells during exhaustion. Nat Immunol 22, 274–276 (2021). https://doi.org/10.1038/s41590-021-00891-8

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