Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

HOST RESPONSE

Gut IgA puts pathogens under pressure

Nature Microbiology volume 6, pages 826–827 (2021)Cite this article

Subjects

Some gut bacterial pathogens can escape antibody-mediated immunity by changing surface-exposed antigens, such as O-antigens. But by using vaccines targeting specific O-antigens to induce immunoglobulin A responses in the gut, such pathogens can also be directed to evolve towards expressing O-antigen variants that impair gut colonization.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Rationally designed vaccination traps pathogenic bacteria through cooperation of acquired and innate immunity.

References

  1. Bogomolnaya, L. et al. Mol. Microbiol. 77, 337–353 (2010).

    Article  Google Scholar 

  2. Diard, M. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-021-00911-1 (2021).

    Article  PubMed  Google Scholar 

  3. Rojas, E. R. et al. Nature 559, 617–621 (2018).

    Article  CAS  Google Scholar 

  4. Aghmohammadi, A. et al. J. Clin. Immunol. 29, 130–136 (2009).

    Article  Google Scholar 

  5. Ludvigsson, J. F., Neovius, M. & Hammarström, L. J. Clin. Immunol. 34, 444–451 (2014).

    Article  CAS  Google Scholar 

  6. Fadlallah, J. et al. Sci. Transl. Med. 10, eaan1217 (2018).

    Article  Google Scholar 

  7. Moor, K. et al. Nature 544, 498–502 (2017).

    Article  CAS  Google Scholar 

  8. Okai, S. et al. Nat. Microbiol. 1, 16103 (2016).

    Article  CAS  Google Scholar 

  9. Nakajima, A. et al. J. Exp. Med. 215, 2019–2034 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Immunology and Infection Control, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan

    Reiko Shinkura

Authors
  1. Reiko Shinkura
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Reiko Shinkura.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shinkura, R. Gut IgA puts pathogens under pressure. Nat Microbiol 6, 826–827 (2021). https://doi.org/10.1038/s41564-021-00925-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-021-00925-9

This article is cited by

Search

Advanced search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology