Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Structural biology

A solution to the telomerase puzzle

Telomerase synthesizes DNA sequences that protect the integrity of chromosome ends. A model for how the components of this enzyme complex co-assemble offers insight into its structure and function. See Article p.187

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The telomerase jigsaw puzzle.

Notes

  1. *This article and the paper5 under discussion were published online on 3 April 2013.

References

  1. Olovnikov, A. M. J. Theor. Biol. 41, 181–190 (1973).

    Article  CAS  Google Scholar 

  2. Harley, C. B., Futcher, A. B. & Greider, C. W. Nature 345, 458–460 (1990).

    Article  ADS  CAS  Google Scholar 

  3. Greider, C. W. & Blackburn, E. H. Cell 43, 405–413 (1985).

    Article  CAS  Google Scholar 

  4. Kim, N. W. et al. Science 266, 2011–2015 (1994).

    Article  ADS  CAS  Google Scholar 

  5. Jiang, J. et al. Nature 496, 187–192 (2013).

    Article  ADS  CAS  Google Scholar 

  6. Mason, M., Schuller, A. & Skordalakes, E. Curr. Opin. Struct. Biol. 21, 92–100 (2011).

    Article  CAS  Google Scholar 

  7. Theimer, C. A. & Feigon, J. Curr. Opin. Struct. Biol. 16, 307–318 (2006).

    Article  CAS  Google Scholar 

  8. Min, B. & Collins, K. Mol. Cell 36, 609–619 (2009).

    Article  CAS  Google Scholar 

  9. Sauerwald, A. et al. Nature Struct. Mol. Biol. 20, 454–460 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael D. Stone.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Akiyama, B., Stone, M. A solution to the telomerase puzzle. Nature 496, 177–178 (2013). https://doi.org/10.1038/nature12090

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature12090

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing