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A prospective national cohort evaluating ring MVA vaccination as post-exposure prophylaxis for monkeypox

  1. Liem Binh Luong Nguyen

    1. Inserm, CIC Cochin Pasteur, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, FranceInserm, F-CRIN, Réseau Innovative Clinical Research in Vaccinology, Paris, France

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  2. Jade Ghosn

    1. Assistance Publique Hôpitaux de Paris, Hôpital Bichat Claude Bernard, Paris, France. Inserm, UMRS 1137 IAME, Paris, France. Université Paris Cité, Paris, France.

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  3. Christine Durier

    1. Inserm, SC-10, Villejuif, France.

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  4. Carla Tachot

    1. Inserm, CIC Cochin Pasteur, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France.

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  5. Eric Tartour

    1. Assistance Publique Hôpitaux de Paris, Hôpital Necker et Hôpital Européen Georges Pompidou, Université de Paris-Cité, Paris, France.

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  6. Amel Touati

    1. Assistance Publique Hôpitaux de Paris, Hôpital Saint-Antoine, Paris, France.

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  7. Tabassome Simon

    1. Assistance Publique Hôpitaux de Paris, Hôpital Saint-Antoine, Paris, France.

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  8. Brigitte Autran

    1. Sorbonne Université INSERM, Centre d'Immunologie et des Maladies Infectieuses–Paris, Hôpital Pitié-Salpêtrière, Paris, France.

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  9. Inmaculata Ortega Perez

    1. ANRS|MIE, Paris, France.

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  10. Erica Telford

    1. ANRS|MIE, Paris, France.

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  11. Jeremy K Ward

    1. Université Paris Cité, CNRS, Inserm, Cermes3, Villejuif, France.EHESS, Cermes3, Villejuif, France.

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  12. David Michels

    1. AIDES, Pantin, France.Laboratoire de Recherche Communautaire, Coalition PLUS, Pantin, France.

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  13. Laurence Meyer

    1. Inserm, SC-10, Villejuif, France.

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  14. Alexandra Rousseau

    1. Assistance Publique Hôpitaux de Paris, Hôpital Saint-Antoine, Paris, France.

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  15. Laurence Berard

    1. Assistance Publique Hôpitaux de Paris, Hôpital Saint-Antoine, Paris, France.

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  16. Xavier de Lamballerie

    1. Unité des Virus Émergents, Aix-Marseille Université, IRD 190, INSERM 1207, IHU Méditerranée Infection, Marseille, France.

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  17. Odile Launay

    1. Inserm, CIC Cochin Pasteur, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France. Inserm, F-CRIN, Réseau Innovative Clinical Research in Vaccinology, Paris, France.Université Paris Cité, Paris, France.

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To the Editor — Monkeypox virus, in the genus Orthopoxvirus, causes regular outbreaks of disease in endemic areas of Central and West Africa1. Since 13 May 2022, cases of monkeypox have been reported in European countries and North America, outnumbering the imported cases from previous outbreaks outside endemic countries2. Previous imported cases have included 71 suspected cases in the United States in 2003, which were due to importation of rodents from Africa, and one nosocomial case from an imported case in the United Kingdom3,4. Transmission seems to happen during close or sexual contact; although monkeypox virus has been detected in the air, there are no confirmed cases of airborne transmission during the current global outbreak.

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Nature Medicine 28, 1983-1984 (2022)

doi: https://doi.org/10.1038/d41591-022-00077-1

Author contributions

L.B.L.N., J.G. and O.L. are the principal investigators of the study and wrote the manuscript. L.B.L.N. prepared the first draft. L.M., C.D. and J.K.M. designed the methodology of the protocol and edited the manuscript. C.D., E.T., T.S., B.A., J.K.W., D.M. and X.L. oversaw the analysis of data and biological samples of the study and edited the manuscript. C.T., A.T., I.M.O.P., E.T., A.R. and L.R. oversaw the management and coordination responsibility of the research. All authors reviewed the manuscript.

Competing interests

L.B.L.N. has received personal fees as a speaker or consultant from Sanofi and Pfizer. O.L. has received personal fees from Sanofi Pasteur; grants, personal fees, and non-financial support from Pfizer, Janssen, and Sanofi Pasteur–Merck Sharp & Dohme; and grants and non-financial support from GlaxoSmithKline. J.G. has received research grants from Gilead Sciences and Merck Sharp & Dohme and personal fees from Gilead Sciences, ViiV Healthcare, Merck Sharp & Dohme, Janssen, Theratechnologies and AstraZeneca. T.S. has received unrestricted research grants from AstraZeneca, Bayer, Boehringer, Daiichi-Sankyo, Eli Lilly, GlaxoSmithKline, Novartis and Sanofi and personal fees from Ablative Solutions, Air Liquide, AstraZeneca, Novartis, 4 living Biotech and Sanofi, for participation on Advisory or data safety monitoring boards, and from Servier and Novartis, for lectures.

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