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Portrait of Kalpana Kalahasti outside in a garden, her arms crossed, wearing a pink and orange sari

Credit: Samyukta Lakshmi for Nature

TEN PEOPLE WHO SHAPED SCIENCE IN 2023

An artificial intelligence (AI) pioneer, an architect of India’s Moon mission and the world’s first global heat officer are among the ten people (and one non-human) behind this year’s big science stories.

Engineer Kalpana Kalahasti helped to orchestrate India’s first successful Moon mission — after a previous one ended in a crash. “I hope young professionals across India and the world get inspired by how the team meticulously emerged from failure,” she says.

Malaria researcher Halidou Tinto’s fight for affordable vaccines became personal when his six-year-old daughter caught malaria. The clinic that Tinto runs in rural Burkina Faso has been instrumental to the approval of the world’s first malaria vaccines.

Brazil’s environment minister Marina Silva helped to rein in rampant logging of the Amazon rainforest. But ending deforestation is not enough, she says. “If countries do not reduce their CO2 emissions from fossil fuels, forests run the risk of being destroyed due to climate change, in the same way.”

This year, Nature’s 10 has an eleventh entry. For the first time, a non-human made it onto the list: ChatGPT. The tool has rekindled the debate about the benefits and risks of AI — and the nature of human intelligence.

Nature | 5 min read per profile

What causes bad ‘morning sickness’

Sensitivity to GDF15, a hormone released by the growing fetus, might be the reason that some people experience hyperemesis gravidarum — debilitating nausea and vomiting during pregnancy. Women who had high levels of the hormone before pregnancy were less likely to develop hyperemesis gravidarum while carrying their baby. People who have low GDF15 levels could be given increasingly high doses of the hormone while trying to conceive, to desensitize them to it, says metabolism researcher and study co-author Stephen O’Rahilly.

Nature | 5 min read

Reference: Nature paper

Bizarre gut microbes are curiously complex

Protists, an overlooked family of microbes that live in the guts of animals such as mice and people, help to shape the gut microbiome and affect their host’s immune responses. Protists are often considered “fourth-class citizens amongst microbes, and they shouldn’t be”, says microbiome researcher Seth Rakoff-Nahoum. In mice, protists kick off a type of immune response in the small intestine. And protists usually win when they compete with gut bacteria.

Nature | 4 min read

Reference: Cell paper

Why frightened mice sleep poorly

Stressed mice experience more blips of wakefulness as certain neurons deep inside the brain become more active. “These neurons are really important for regulating sleep stability, for sleep continuity, so that your sleep is not fragmented,” explains neuroscientist and study co-author Shinjae Chung. Short wakefulness spells are a normal part of sleep — but in mice that had been attacked repeatedly by an aggressive cage mate, they occurred more frequently.

Nature | 5 min read

Reference: Current Biology paper

Biologist loses disability case

Paediatric neurologist and RNA biologist Vivian Cheung lost her discrimination case against her former employer, who she alleged had terminated her funding owing to her disability. Cheung’s claim was rejected by a jury after just three hours of deliberation. Some researchers are disappointed with the outcome. “I could absolutely see a case like this dissuading other disabled people from bringing their claims forward,” says disabled veteran and lab manager Nathan Tilton.

Nature | 6 min read

Features & opinion

Research returns to Chornobyl

The exclusion zone surrounding the Chornobyl nuclear power plant had been a science hotspot until it became part of the front line of the Ukraine war. Now, the land is dotted with mines and remains that are partially under military control. Yet some researchers are finding ways to restart their work. Ecologist Bohdan Prots, for example, is working to recreate the zone’s lost wetlands and cut the risks of wildfires that spread radioactivity — a project that has drawn fresh interest because swamps could hold off Russian troops. “This could be a big win of this war: to have restored moist wetlands,” Prots says.

Nature | 11 min read

DIY scientists make their own tools

When budgets are tight and the right tool does not exist, inventive researchers make their own. Synthetic biologist Erika Debenedictis designed a robot to babysit the evolution of viral proteins. Materials scientist Nick McCormick developed a camera system to check that old railway tunnels remain safe. And analytical scientist Dušan Materić built a machine that analyses microplastics in snow samples. “Inventions come from going out on a limb,” says Debenedictis, whose robot prompted the generation of two academic laboratories and a start-up company.

Nature | 9 min read

Video: The rubber that stops cracks

A type of rubber that looks like entangled spaghetti on a molecular scale is ten times more durable than normal rubber. Interlinked polymer strands make standard reinforced rubber — the type used in tyres and shock absorbers — rigid but brittle. The new rubber contains much longer, entangled polymer strands, which helps to diffuse the mechanical stress from the edge of a crack.

Nature | 3 min video

Reference: Nature paper

Quote of the day

“Unlike most people, scientists and science communicators often tend to think humans are in a sense nothing special.”

Medical doctor Chris Ellis says that science communicators should consider a more sensitive and anthropological approach rather than focusing on the ultimate meaningless of life. (The Conversation | 5 min read)