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  • RESEARCH HIGHLIGHT

Doubling down on osteoarthritis

  1. Katie Kingwell
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Osteoarthritis is a major cause of disability and has no cure. Loss of cartilage is a key driver of this disease, making cartilage regeneration an attractive therapeutic strategy. Now, two papers in Science Translational Medicine from the laboratory of Francesco Dell’Accio and collaborators highlight blockade of receptor tyrosine kinase-like orphan receptor 2 (ROR2) and administration of agrin as two potential approaches to promote cartilage formation.

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Nature Reviews Drug Discovery 19, 753 (2020)

doi: https://doi.org/10.1038/d41573-020-00174-1

References

  1. Thorup, A.-S. et al. ROR2 blockade as a therapy for osteoarthritis. Sci. Transl Med. 12, eaax3063 (2020)

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  2. Eldridge, S. E. et al. Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis. Sci. Transl Med. 12, eaax9086 (2020)

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