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Graft-Versus-Host Disease

Specific self-antigen-driven immune response in pericardial effusion as an isolated GVHD manifestation

Bone Marrow Transplantation volume 45, pages 1084–1087 (2010)Cite this article

Abstract

Pericardial effusion and cardiac tamponade have been described as GVHD manifestations in the post transplant period. Direct evidence of GVHD-related TCR or B-cell receptor clones in patients with pericardial effusion has never been described. Using several methods, including FACS and spectratyping analysis to assess T- and B-cell clonality and to quantify TCR excision circles to assess newly thymus-derived T cells, we were able to show expansion of oligoclonal T-cell populations and the possible presence of early/premature B cells in the pericardial effusion but not in peripheral mononuclear cells. This may explain the presentation of an isolated GVHD manifestation.

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Authors and Affiliations

  1. Cancer Research Center, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv, Israel

    A Lev, N Amariglio, G Rechavi & R Somech

  2. Hematology Laboratory, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv, Israel

    N Amariglio

  3. Pediatric Immunology Service, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv, Israel

    Z Spirer & R Somech

  4. Pediatric Cardiology Clinic, The E. Safra Congenital Heart Disease Center, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv, Israel

    U Katz

  5. Pediatric Hematology/Oncology Division, Bone Marrow Transplantation Unit, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv, Israel

    B Bielorai

Authors
  1. A Lev
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  2. N Amariglio
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  3. Z Spirer
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  4. U Katz
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  6. G Rechavi
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  7. R Somech
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Correspondence to R Somech.

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Lev, A., Amariglio, N., Spirer, Z. et al. Specific self-antigen-driven immune response in pericardial effusion as an isolated GVHD manifestation. Bone Marrow Transplant 45, 1084–1087 (2010). https://doi.org/10.1038/bmt.2009.314

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  • DOI: https://doi.org/10.1038/bmt.2009.314

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