Abstract
The Minnesota Children's Pesticide Exposure Study (MNCPES) of the National Human Exposure Assessment Survey (NHEXAS) was conducted in Minnesota to evaluate children's pesticide exposure. This study complements and extends the populations and chemicals included in the NHEXAS Region V study. One of the goals of the study was to test protocols for acquiring exposure measurements and developing databases for use in exposure models and assessments. Analysis of the data quality is one element in assessing the performance of the collection and analysis protocols used in this study. Data quality information must also be available to investigators to guide analysis of the study data. During the planning phase of MNCPES, quality assurance (QA) goals were established for precision, accuracy, and quantification limits. The data quality was assessed against these goals. The assessment is complex. First, data are not available for all analytes and media sampled. In addition, several laboratories were responsible for the analysis of the collected samples. Each laboratory provided data according to their standard operating procedures (SOPs) and protocols. Detection limits were authenticated for each analyte in each sample type. The approach used to calculate detection limits varied across the different analytical methods. The analytical methods for pesticides in air, food, hand rinses, dust wipe and urine were sufficiently sensitive and met the QA goals, with very few exceptions. This was also true for polynuclear aromatic hydrocarbons (PAHs) in air and food. The analytical methods for drinking water and beverages had very low detection limits; however, there were very little measurable data for these samples. The collection and analysis methods for pesticides in surface press samples and soil, and for PAHs in dust wipes were not sufficiently sensitive. Accuracy was assessed primarily as recovery from field controls. The results were good for pesticides and PAHs in air (75–125% recovery). Recovery was lower (<75%) for pesticides in drinking water and beverages. The recovery of pesticides from hand rinses met QA goals (75–100%), but surface press samples showed lower recovery (50–70%). Analysis by gas chromatography-mass spectrometry (GC–MS) did not confirm the presence of atrazine and other pesticides in hand rinse and surface press samples that had been detected by GC-ECD, but instead GC–MS confirmed background interferences. Assessment of the precision of sample collection and analysis is based on the percent relative standard deviation (%RSD) between the results for duplicate samples. Data are available only for pesticides and PAHs in air. Precision was good (<20% RSD) for analytes with measurable data. There were a few analytes with %RSD >20%, but the number of data pairs was very small in these cases. Precision for instrumental analysis of food sample extracts was excellent, with the median %RSD < 20 for all measurable pesticides. The median %RSD for the analysis of replicate aliquots of food from the same sample composite was considerably higher, indicating the potential for inhomogeneity of food homogenates.
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Notes
QSIP document also contains a full description of the analytical protocols and quality control and assurance procedures employed. It is available from the US EPA, NERL (MC-HERB), PO Box 93478, Las Vegas, NV 89193, USA.
Abbreviations
- GC-ECD:
-
gas chromatography-electron capture detection
- GC–MS:
-
gas chromatography–mass spectrometry
- FC:
-
field control
- FSD:
-
full-scale deflection
- K-D:
-
Kuderna-Danish
- LOQ:
-
limit of quantification
- LWW:
-
Lioy–Wainman–Weisel sampler
- MC:
-
method control
- MDL:
-
method detection limit
- MNCPES:
-
Minnesota Children's Pesticide Exposure Study
- NHEXAS:
-
National Human Exposure Assessment Survey
- NIST:
-
National Institute of Science and Technology
- NOPES:
-
Nonoccupational Pesticide Exposure Study
- %CV:
-
coefficient of variation in percent
- PAHs:
-
polynuclear aromatic hydrocarbons
- PFT:
-
perfluorotoluene
- QA:
-
Quality assurance
- QC:
-
quality control
- QL:
-
quantification limit
- QSIP:
-
Quality Systems Implementation Plan
- SOPs:
-
standard operating procedures
- SRM:
-
standard reference materials
- RSD:
-
relative standard deviation
- TEAM:
-
Total Exposure and Assessment Methodology
- US EPA:
-
United States Environmental Protection Agency.
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Acknowledgements
We thank the participating laboratories for providing their adroit assistance in analyzing NHEXAS samples. The US Environmental Protection Agency (EPA), through its Office of Research and Development (ORD), funded and performed the research under Cooperative Agreement CR821902-01-0 and the analysis of results under Contract Number 68-D-99-008. This manuscript has been peer reviewed by EPA and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
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Pellizzari, E., Smith, D., Andrew Clayton, C. et al. Assessment of data quality for the NHEXAS — Part II: Minnesota children's pesticide exposure study (MNCPES). J Expo Sci Environ Epidemiol 13, 465–479 (2003). https://doi.org/10.1038/sj.jea.7500315
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DOI: https://doi.org/10.1038/sj.jea.7500315
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